dna width orders of magnitude vs transistor gate

Nanogap Detector (Arrays) Inside Nanofluidic Channel for Fast Real-Time DNA Sequencing Genomic sequencing at these reduced costs would make vital contributions to improved human health on many fronts, including the understanding, diagnosis, treatment, and prevention of disease environmental science and remediation and the genetics of human health and disease derived from the understanding of evolution. Design a third generation nanopore detector for high throughput 10 Kb/sec/nanopore sequencing.If we are able to resolve each base as it passes through a nanopore at the rate of 104 bases/sec as proposed here, an instrument with an array of 100 such nanopores could produce a high quality draft sequence of one mammalian genome in ~20 hours at a cost of approximately $1,000/mammalian genome.Design and fabricate a second generation detector with embedded 'T' nanotube geometry and achieve 1 Kb/sec sequencing on Kb length strands of DNA.Analyze and optimize tunneling current modulations between gapped nanotube electrodes in the first generation detector.Study and optimize DNA molecule induced field effect modulation of nanotube electrode conductance in ungapped nanotube articulated nanopores as a function of nanotube bias, gate voltage, and solution properties.Control ssDNA binding, translocation, and sliding on the nanotube surface exposed in ungapped nanotube articulated nanopores.Characterize ungapped nanotube articulated nanopore detectors in ionic solution with and without DNA molecules to establish a device model.The final system is intended to provide a relatively high quality sequence from =6.5-fold coverage of a genome using DNA from fewer than 1 million cells, with no amplification or labeling. The instrument directly generates base-dependent electronic signals as multi-kilobase length fragments of single stranded genomic DNA is driven sequentially through nanopores articulated with electrically contacted single walled carbon nanotube probes. The long-term objective is a nanopore detector chip for a general utility instrument capable of inexpensive de novo sequencing that can also be used for re-sequencing projects. '$1,000 Genome' Grants Electronic Sequencing in Nanoporesīranton, Daniel, and Golovchenko, Jene A. The 2008 awards were announced on Aug(See: NHGRI Seeks DNA Sequencing Technologies Fit for Routine Laboratory and Medical Use ) The National Human Genome Research Institute (NHGRI) has continued its coordinated effort to support the development of technologies to dramatically reduce the cost of DNA sequencing, a move aimed at broadening the applications of genomic information in medical research and health care. Advanced Sequencing Technology Awards 2008

Dna width orders of magnitude vs transistor gate